Salt has shaped human civilization in ways few other substances have. Long before processed food and drive-thru meals, salt determined the survival and prosperity of entire communities. Ancient societies traded it across deserts and oceans, fought over its sources, and revered it as a near-sacred commodity. The English word “salary” comes from “salarium,” the term for payments that included salt rations given to Roman soldiers. These early civilizations understood something simple: without salt, life is not possible.
In modern nutrition debates, though, salt is often reduced to a one-dimensional villain. It is blamed for high blood pressure, fluid retention, bloating, and cardiovascular disease. Food companies have used it to engineer hyper-palatable processed products, while public health agencies have issued stern warnings to cut back. Somewhere in the collision between ancient reverence and modern overconsumption, nuance has been lost.
Salt is essential, but it is not something to consume recklessly. It requires context. Your biology, your diet as a whole, and your activity level all determine whether salt is supporting your health or undermining it. This series will help you understand why salt matters, when it becomes a problem, and how to navigate recommendations that often feel contradictory.
Sodium’s Role in the Body
Sodium is one of the most important electrolytes in human physiology. It regulates the volume of fluid in your blood vessels, maintains acid-base balance, supports nerve conduction, and enables muscle contraction. Without enough sodium, your cells cannot maintain proper electrical gradients, and essential functions begin to break down (1).
When you eat salt—chemically known as sodium chloride—your digestive system absorbs sodium into the bloodstream. Specialized receptors in the kidneys, called macula densa cells, detect the concentration of sodium and adjust excretion accordingly. This feedback loop involves several hormones, most notably aldosterone, which tells the kidneys to reabsorb sodium if levels are low (2).
For most of human history, sodium was scarce in natural diets. Hunter-gatherers consumed far less sodium than modern humans, and their kidneys evolved to conserve every gram. This conservation made sense when salt was difficult to obtain. But today, this same system struggles to manage diets that can exceed 3,500–4,000 milligrams of sodium daily, mostly from processed foods (3).
💡 Key Takeaway: Sodium is a fundamental electrolyte that keeps your fluid balance, nerve impulses, and muscles functioning, but the body’s conservation systems evolved under conditions of scarcity rather than modern excess.
The Spectrum of Sodium Intake
The modern conversation about sodium often polarizes into extremes. On one end are those who argue salt should be minimized at all costs, citing evidence linking sodium to hypertension and cardiovascular mortality. On the other end are proponents who suggest salt is harmless and should be consumed freely, especially in the context of low-carbohydrate or ancestral diets. The truth is more complex than either narrative admits.
Large epidemiological studies have shown that sodium intake and cardiovascular risk do not follow a simple linear relationship. Instead, the data often form a J-shaped curve: risk appears to increase at both very high and very low intakes (4). For example, the PURE study, a massive multinational analysis, observed that people with sodium intake below 3,000 milligrams and above 5,000 milligrams per day had higher rates of cardiovascular events compared to moderate intake ranges (5).
This observation does not mean everyone should aim for the same target. Some individuals are “salt sensitive,” meaning their blood pressure rises significantly when they consume more sodium. Others are “salt resistant” and experience little change in blood pressure, even with high intake. Age, ethnicity, kidney function, insulin sensitivity, and even gut microbiome composition can all influence how sodium affects your physiology (6).
💡 Key Takeaway: Neither extremely low nor extremely high sodium intake is universally beneficial. Individual risk depends on many factors, creating a J-shaped relationship between sodium and health outcomes.
Salt Sensitivity and Individual Response
Salt sensitivity is one of the most important and least discussed variables in the sodium debate. In salt-sensitive individuals, sodium intake increases extracellular fluid volume and systemic vascular resistance more dramatically than in salt-resistant people. These physiological changes translate to higher resting blood pressure and greater cardiovascular strain over time.
Research suggests that about 25% of normotensive (normal blood pressure) adults and up to 50% of hypertensive adults are salt sensitive. Prevalence is higher among older adults, African Americans, and individuals with chronic kidney disease (6). This is why universal sodium recommendations can be problematic: some people benefit significantly from reducing sodium intake, while others may see little impact.
Salt sensitivity testing typically involves controlled feeding studies or monitoring blood pressure response to sodium loading and restriction. In practice, such testing is rarely performed outside research settings. For most people, individualized monitoring of blood pressure response to dietary sodium adjustments remains the most accessible strategy.
💡 Key Takeaway: Salt sensitivity varies widely between individuals. Some people experience significant rises in blood pressure with higher sodium intake, while others see little change.
The Historical Perspective on Salt
Understanding salt requires revisiting its place in human culture. In ancient Rome, soldiers were partly compensated with “salarium,” a salt allowance that eventually lent its name to the word “salary.” Salt routes connected Africa, Asia, and Europe. The expression “worth one’s salt” emerged from this era of trade and reliance (1).
Salt also played critical roles in food preservation. Before refrigeration, salt enabled societies to store meat, fish, and vegetables, which was essential for survival during winters or long journeys. This reliance imbued salt with symbolic value. It was considered a purifier, a preservative of life, and even a sacred substance in some cultures.
Today, salt has transitioned from scarcity to overabundance. The same substance once valued like gold is now a cheap, invisible ingredient in thousands of packaged foods. Recognizing this historical swing from necessity to excess can help frame modern discussions more thoughtfully.
💡 Key Takeaway: Salt has moved from being a prized and scarce resource to an abundant additive, which has fundamentally changed how we consume and perceive it.
Sodium and Cardiovascular Health
One of the central reasons sodium became a nutritional scapegoat is its established relationship with blood pressure. When sodium intake increases, blood volume expands because sodium attracts water into the bloodstream. This higher volume requires the heart to work harder to pump blood through the circulatory system, resulting in elevated pressure on the arterial walls. Over time, chronically elevated pressure can damage the endothelium, which is the thin lining inside arteries, promoting inflammation, plaque formation, and increased risk of cardiovascular disease (7).
However, this relationship is not as straightforward as it was once portrayed. While observational studies consistently find a correlation between higher sodium intake and elevated blood pressure, they also reveal that individual variability is substantial. The Trials of Hypertension Prevention (TOHP) demonstrated that reducing sodium modestly—by about 25%—led to modest decreases in blood pressure, averaging 2–4 mm Hg systolic in normotensive adults (8). In hypertensive populations, reductions were more significant, but still variable.
Additionally, some studies have raised questions about very low sodium intake. Data from large cohort analyses, such as the PURE study, suggest that consuming less than 3 grams of sodium per day can paradoxically increase mortality, potentially through activation of the renin-angiotensin-aldosterone system and sympathetic nervous system (9).
When sodium intake drops too low, the body activates compensatory hormones such as renin, aldosterone, and noradrenaline to maintain circulation. While these mechanisms help preserve fluid balance, some researchers have raised concerns that chronic activation may place additional strain on cardiovascular function (10).
This does not mean sodium reduction is ineffective. Rather, it underscores the importance of context. People with hypertension and high sodium diets typically benefit from reductions, while individuals with normal blood pressure and balanced diets may not experience significant improvements or could potentially experience harm if intake drops too low (11).
💡 Key Takeaway: Sodium’s impact on cardiovascular health depends heavily on individual risk factors. While reducing sodium can help lower blood pressure, especially in hypertensive people, excessively low intake can trigger hormonal adaptations that strain the heart.
Sodium, Potassium, and the Balance Problem
One of the most overlooked aspects of sodium’s health effects is the counterbalancing role of potassium. Potassium is another electrolyte essential for nerve conduction, fluid balance, and muscle contraction. It also plays a direct role in regulating blood pressure by encouraging sodium excretion through the kidneys and relaxing the walls of blood vessels (12).
Research has consistently shown that populations consuming diets high in potassium experience lower blood pressure and reduced cardiovascular risk, even when sodium intake is moderate or high. The DASH (Dietary Approaches to Stop Hypertension) trial highlighted this interaction powerfully. Participants who increased their intake of fruits and vegetables—natural potassium sources—while reducing sodium saw significantly greater improvements in blood pressure than those reducing sodium alone (13).
Modern diets create a dual imbalance: excessive sodium and insufficient potassium. This combination amplifies the hypertensive effect of sodium because there is no counter-regulatory mechanism operating effectively. Ancient diets often contained far more potassium than sodium, sometimes by a factor of 2 or 3 to 1. Today, processed foods have flipped that ratio, often delivering three times as much sodium as potassium.
Restoring this balance is not simply a matter of cutting salt but also adding more potassium-rich foods. Leafy greens, legumes, potatoes, bananas, squash, and avocados all contain high levels of potassium and other beneficial micronutrients. When these foods are included in sufficient quantities, the need for strict sodium restriction diminishes in many people, because potassium supports natural excretion and vascular relaxation.
💡 Key Takeaway: Potassium moderates sodium’s impact on blood pressure and cardiovascular risk. High-sodium diets are more harmful when potassium intake is low, which is common in modern processed food patterns.
Sodium and Insulin Resistance
Another dimension of sodium’s health effects is its relationship with insulin resistance and metabolic health. While this topic is less frequently discussed, it is increasingly relevant as metabolic syndrome and type 2 diabetes become more prevalent globally. Some studies have suggested that high sodium intake may impair insulin sensitivity, particularly when combined with low potassium intake and excessive caloric consumption (14).
Mechanistically, sodium-induced increases in blood pressure can reduce microvascular function, impairing glucose uptake in skeletal muscle. This effect is more pronounced in salt-sensitive individuals, where higher sodium intake raises sympathetic nervous system activity, contributing to insulin resistance (14). Elevated insulin itself can also promote renal sodium reabsorption, creating a feedback loop in which insulin resistance and sodium retention reinforce each other.
Conversely, some researchers argue that the link between sodium and insulin resistance is primarily driven by dietary confounders. Diets high in sodium often include processed carbohydrates, trans fats, and low nutrient density, all of which independently contribute to insulin dysfunction. For example, processed meats, snack foods, and fast foods combine sodium with refined grains and sugars, making it difficult to isolate sodium’s precise contribution.
While the evidence is not yet conclusive, these observations suggest that metabolic health should inform sodium recommendations. Individuals with insulin resistance, prediabetes, or type 2 diabetes may be more vulnerable to the vascular effects of sodium and may benefit from moderated intake alongside improved diet quality overall.
💡 Key Takeaway: Sodium may contribute to insulin resistance indirectly by impairing microvascular circulation and interacting with hormonal pathways. Diet quality and metabolic health strongly influence how sodium affects glucose metabolism.
Sodium and Fluid Retention
One of the most visible and often frustrating consequences of high sodium intake is fluid retention. Sodium draws water into the extracellular space, expanding plasma volume and sometimes causing swelling in the hands, feet, and face. For individuals tracking their body weight, this can result in rapid increases of several pounds over a day or two, which can be confusing and discouraging during fat loss efforts (1).
Fluid retention does not necessarily reflect fat gain, but it can have real physiological consequences. In people with heart failure or kidney disease, sodium-induced fluid accumulation can overwhelm the body’s compensatory mechanisms, exacerbating hypertension, pulmonary congestion, and edema. Even in otherwise healthy individuals, large sodium fluctuations can cause uncomfortable bloating and transient increases in blood pressure.
This effect also has performance implications for athletes. Some endurance athletes use sodium loading intentionally to expand plasma volume before events, improving thermoregulation and delaying dehydration. However, in less controlled settings, excessive sodium without appropriate fluid management can lead to blood pressure spikes and discomfort.
Practical strategies to manage fluid retention include monitoring total sodium intake, increasing potassium consumption, and ensuring adequate hydration. Sudden increases or decreases in sodium intake often create more noticeable fluctuations, so consistency is preferable when possible.
💡 Key Takeaway: Sodium affects fluid retention by drawing water into circulation and tissues. While not inherently harmful in healthy people, large fluctuations can cause bloating, transient weight gain, and discomfort.
Sodium in Low-Carbohydrate Diets
Low-carbohydrate and ketogenic diets have surged in popularity as strategies for weight loss, glycemic control, and metabolic health. These diets introduce additional considerations for sodium balance. When carbohydrate intake drops, insulin levels decline, reducing the kidney’s reabsorption of sodium. This accelerates sodium and water excretion—a phenomenon known as natriuresis (15).
Many individuals transitioning to a low-carbohydrate diet experience rapid fluid loss in the first week, sometimes accompanied by fatigue, headaches, dizziness, and muscle cramps. These symptoms are often labeled “keto flu,” though they are primarily signs of sodium and fluid depletion rather than carbohydrate withdrawal per se (15).
Research suggests that increasing sodium intake during this period can alleviate many of these symptoms. A review of ketogenic diet protocols highlights the importance of maintaining adequate electrolyte intake, recommending 3–5 grams of sodium per day for individuals on strict ketogenic regimens, particularly during the adaptation phase (16). This is significantly higher than standard recommendations but reflects the altered physiology of carbohydrate restriction.
It is important to note that while higher sodium intake is appropriate in this context, it should still be balanced with adequate potassium and magnesium. Salt alone does not fully correct electrolyte imbalances that can arise during low-carbohydrate adaptation.
💡 Key Takeaway: Low-carbohydrate diets increase sodium excretion due to lower insulin levels, creating higher sodium requirements to prevent fatigue, headaches, and muscle cramps.
Sodium and Aging
Aging introduces further complexity into sodium regulation. Older adults often experience declines in kidney function, reduced thirst perception, and altered hormonal responses that collectively impair sodium and fluid balance (17). These physiological changes can make older adults more susceptible to both sodium overload and sodium depletion.
One concern is that diminished renal function reduces the kidney’s capacity to excrete sodium efficiently. This can lead to higher resting blood pressure and greater cardiovascular strain when sodium intake is excessive. Conversely, older adults are also at increased risk of hyponatremia, particularly when using medications such as diuretics, antidepressants, or nonsteroidal anti-inflammatory drugs, which affect sodium and water handling.
These dual vulnerabilities mean that sodium recommendations for older adults must be individualized. Blanket restrictions may not be appropriate for all seniors, especially those with low sodium intake and increased diuretic use. Clinical monitoring of serum sodium levels, blood pressure, and fluid status is often warranted in this population to balance risks of hypertension and hyponatremia.
Strategies to support healthy sodium balance in older adults include consistent fluid intake, moderate sodium consumption (rather than aggressive restriction), and dietary patterns rich in potassium and magnesium. Regular health assessments are critical to adapt recommendations as physiology and medication use change with age.
💡 Key Takeaway: Aging impairs sodium regulation through changes in kidney function and hormonal balance. Older adults require careful, individualized sodium guidance to avoid both excess and deficiency.
Salt and Processed Food Culture
One of the most significant contributors to excessive sodium intake is the widespread reliance on processed and packaged foods. In most industrialized nations, more than 70% of dietary sodium comes not from salt added at the table but from restaurant meals, packaged snacks, canned soups, deli meats, and ready-to-eat products (18).
These foods often contain sodium for multiple reasons: flavor enhancement, preservation, texture improvement, and even as a bulking agent. Manufacturers have long used sodium-based additives to extend shelf life and reduce spoilage, which was initially seen as a public health improvement when refrigeration was limited. Over time, however, the convenience of processed foods has transformed dietary sodium from an occasional preservative to a constant presence.
This shift has disconnected many people from their natural ability to regulate salt intake by taste. When all foods are pre-seasoned and hyper-palatable, it becomes harder to notice the difference between moderate and excessive sodium consumption. Studies show that individuals accustomed to high-sodium diets have dampened taste sensitivity to salt, requiring higher amounts to achieve the same perceived flavor intensity (19).
The dominance of processed foods also correlates with other dietary risks. These products tend to be low in potassium, magnesium, fiber, and phytonutrients while providing high levels of refined carbohydrates and industrial fats. In this context, sodium is only one piece of a broader nutritional imbalance that contributes to hypertension, cardiovascular disease, and metabolic dysfunction.
Strategies to reduce sodium in this environment must go beyond simply removing the salt shaker. Preparing meals from whole foods, reading labels carefully, and choosing minimally processed options can dramatically lower sodium intake while improving overall diet quality.
💡 Key Takeaway: Most dietary sodium comes from processed foods, not discretionary use. Reducing sodium effectively requires shifting toward whole, minimally processed meals.
Sodium in Cultural and Regional Contexts
Sodium consumption patterns vary widely across cultures and regions. Traditional Japanese and Korean diets, for example, are often high in sodium due to fermented condiments such as soy sauce, miso, and kimchi. Despite this, some populations historically maintained lower rates of cardiovascular disease, suggesting that other dietary and lifestyle factors play protective roles (18).
In Mediterranean regions, sodium intake can also be substantial, but diets are balanced by high consumption of potassium-rich vegetables, legumes, and olive oil, as well as active lifestyles. These factors illustrate that sodium’s health impact does not occur in isolation but is shaped by broader dietary patterns and cultural practices (18).
Conversely, in North America and parts of Europe, high sodium intake frequently coexists with low physical activity, high consumption of processed carbohydrates and saturated fats, and low intake of potassium and fiber. This combination creates a metabolic environment where sodium contributes more significantly to disease risk.
Public health recommendations often fail to account for these cultural nuances. For example, sodium reduction campaigns sometimes encounter resistance in cultures where salty condiments have deep culinary and social significance. Addressing sodium intake in such contexts requires culturally sensitive strategies that respect traditional practices while supporting gradual improvements in diet quality.
💡 Key Takeaway: Cultural dietary patterns and lifestyle factors shape sodium’s health impact. High-sodium diets can be less harmful when combined with nutrient-rich whole foods and active living.
Sodium, Stress, and the Nervous System
Emerging research is exploring how sodium intake interacts with stress physiology and nervous system regulation. High sodium intake has been linked to increased sympathetic nervous system activity, which can raise heart rate, tighten blood vessels, and elevate blood pressure (20). This pathway is distinct from the fluid retention mechanism and involves direct neural activation.
Chronic stress itself promotes sodium retention through elevated cortisol and aldosterone, hormones that increase reabsorption of sodium by the kidneys. This creates a feedback loop in which stress elevates sodium levels, and higher sodium intake sustains sympathetic activation, compounding cardiovascular strain over time.
Additionally, studies in animal models have shown that sodium can influence brain circuits involved in reward and motivation. High-sodium diets have been associated with altered dopamine signaling, which may partly explain why salty processed foods feel especially satisfying under stress (20).
Although the implications for humans are still being studied, these findings highlight how sodium’s role extends beyond fluid balance to include direct effects on the nervous system and behavioral patterns. Individuals experiencing chronic stress may be more vulnerable to the negative cardiovascular impacts of high sodium intake and more prone to seek out salty comfort foods.
Practical strategies to break this cycle include incorporating stress management techniques such as deep breathing, meditation, and physical activity, alongside gradual dietary changes to reduce reliance on hyper-salted processed foods.
💡 Key Takeaway: Sodium intake interacts with stress and nervous system activity, creating a feedback loop that elevates cardiovascular risk and promotes cravings for salty foods.
Sodium Labeling and Public Health Policy
Over the past two decades, public health agencies have introduced multiple strategies to help consumers reduce sodium intake. Food labeling laws now require sodium content to be clearly listed on packaged products, and some jurisdictions have implemented front-of-package warnings for high-sodium items (21).
Restaurant chains in several countries are also required to disclose sodium levels, a move intended to empower diners to make informed choices. However, research suggests that awareness alone may not be sufficient to drive meaningful reductions in intake. In studies of labeling effectiveness, a significant proportion of consumers continued to choose high-sodium options despite clear warnings (21).
Food reformulation initiatives have had more success. Voluntary and mandatory targets have been set in many regions to lower sodium in categories such as bread, processed meats, and snack foods. These policies have produced measurable declines in population-level sodium consumption in some countries, though progress remains uneven.
A key challenge is that sodium serves functional purposes in food manufacturing beyond flavor. Removing or reducing it requires changes in production methods, preservation techniques, and sometimes packaging, all of which create cost and logistical barriers.
While labeling and reformulation are important tools, experts increasingly advocate for a broader approach that includes education on cooking skills, improved access to whole foods, and community-level initiatives to shift dietary norms.
💡 Key Takeaway: Labeling and reformulation policies have contributed to sodium reduction, but broader strategies addressing food culture and access are necessary for sustained change.
Personalized Sodium Strategies
After exploring sodium’s complex relationship with health, performance, and culture, it becomes clear that blanket recommendations often fail to serve individuals effectively. Personalized sodium strategies consider your baseline health status, activity level, dietary patterns, and environmental factors.
For example, if you are sedentary, overweight, and consuming a diet dominated by processed foods, reducing sodium intake can have measurable benefits for blood pressure and cardiovascular risk (25). In contrast, if you are an endurance athlete training in hot conditions, maintaining higher sodium intake supports hydration, performance, and recovery.
Older adults managing multiple medications must account for sodium’s interactions with diuretics, blood pressure drugs, and other treatments. People transitioning to low-carbohydrate diets will often benefit from temporarily increasing sodium to counter rapid excretion during adaptation.
Personalization starts with awareness: reading labels, understanding your salt sensitivity, and monitoring how your body responds to adjustments. Blood pressure tracking at home, combined with dietary journaling, offers practical insights into your individual needs.
No single sodium target is universally correct. The healthiest approach acknowledges sodium’s essential roles while respecting each person’s unique biology and circumstances.
💡 Key Takeaway: Personalized sodium intake considers health status, activity, diet, and environment. No single guideline fits everyone.
Reframing Salt in a Modern Diet
Reframing salt requires moving beyond fear or indulgence. Rather than demonizing or glorifying sodium, you can see it as a powerful nutrient that needs context and balance.
Salt remains an irreplaceable component of taste, preservation, and physiological function. Ancient cultures valued it as a life-sustaining substance, a perspective that modern science continues to validate. But today’s challenges are different. Cheap, abundant processed foods have transformed salt from a precious resource into an almost invisible excess.
Recognizing this shift enables a more constructive relationship with sodium. Instead of reacting to sensational headlines, you can make thoughtful decisions about how much salt you consume and where it comes from. Replacing packaged foods with whole, potassium-rich options is the single most effective step to recalibrate your sodium intake without micromanagement.
When you view salt not as an enemy but as a necessary element requiring respect, you can avoid the extremes of overconsumption and unnecessary deprivation. This mindset empowers sustainable choices that align with your health goals.
💡 Key Takeaway: Reframing your relationship with salt allows you to use it wisely without fear, respecting its role as both a vital nutrient and a potential risk factor.
FAQ
Q: Is sea salt better than table salt?
A: Sea salt contains trace minerals and often has a different taste, but its sodium content is similar. For health purposes, the main difference is preference and minimal mineral content, not substantial benefits.
Q: How do I know if I am salt sensitive?
A: If you notice significant increases in blood pressure when consuming higher sodium, you may be salt sensitive. Discussing home monitoring or clinical testing with your healthcare provider can help clarify.
Q: Do athletes need more salt?
A: Yes, especially in prolonged or intense exercise, athletes lose substantial sodium through sweat. Intake should be adjusted to match training demands.
Q: Should I track sodium intake daily?
A: Most people don’t need to track every milligram but should be aware of hidden sources in processed foods and aim for consistency rather than extreme swings.
Q: Can low sodium intake be harmful?
A: Very low intake can trigger compensatory hormones that may strain the cardiovascular system. Individual needs vary, so drastic reduction should be approached cautiously.
✏︎ Bottom Line
Salt is neither a universal villain nor an unlimited indulgence. It has shaped our history, sustained civilizations, and continues to be an essential nutrient. By understanding how sodium interacts with your body, activity, and broader diet, you can make informed choices that avoid the traps of modern excess while preserving this ancient element’s rightful place in a balanced life.
If you are ready to see how your own sodium intake fits into your daily habits, PlateauBreaker™ makes it simple to track sodium and other key nutrients so you can make informed decisions about your nutrition.
Bibliography
- He, F J, and G A MacGregor. “A comprehensive review on salt and health and current experience of worldwide salt reduction programmes.” Journal of human hypertension vol. 23,6 (2009): 363-84. doi:10.1038/jhh.2008.144. https://pubmed.ncbi.nlm.nih.gov/19110538/
- O’Donnell, Martin et al. “Urinary sodium and potassium excretion, mortality, and cardiovascular events.” The New England journal of medicine vol. 371,7 (2014): 612-23. doi:10.1056/NEJMoa1311889. https://pubmed.ncbi.nlm.nih.gov/25119607/
- Weinberger, M H. “Salt sensitivity of blood pressure in humans.” Hypertension (Dallas, Tex. : 1979) vol. 27,3 Pt 2 (1996): 481-90. doi:10.1161/01.hyp.27.3.481. https://pubmed.ncbi.nlm.nih.gov/8613190/
- Felder, Robin A et al. “G protein-coupled receptor kinase 4 gene variants in human essential hypertension.” Proceedings of the National Academy of Sciences of the United States of America vol. 99,6 (2002): 3872-7. doi:10.1073/pnas.062694599. https://pubmed.ncbi.nlm.nih.gov/11904438/
- O’Donnell, Martin et al. “Urinary sodium and potassium excretion, mortality, and cardiovascular events.” The New England journal of medicine vol. 371,7 (2014): 612-23. doi:10.1056/NEJMoa1311889. https://pubmed.ncbi.nlm.nih.gov/25119607/
- Alderman, M H et al. “Low urinary sodium is associated with greater risk of myocardial infarction among treated hypertensive men.” Hypertension (Dallas, Tex. : 1979) vol. 25,6 (1995): 1144-52. doi:10.1161/01.hyp.25.6.1144. https://pubmed.ncbi.nlm.nih.gov/7768554/
- Widlansky, Michael E et al. “The clinical implications of endothelial dysfunction.” Journal of the American College of Cardiology vol. 42,7 (2003): 1149-60. doi:10.1016/s0735-1097(03)00994-x. https://pubmed.ncbi.nlm.nih.gov/14522472/
- “Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. The Trials of Hypertension Prevention Collaborative Research Group.” Archives of internal medicine vol. 157,6 (1997): 657-67. https://pubmed.ncbi.nlm.nih.gov/9080920/
- Taylor, Rod S et al. “Reduced dietary salt for the prevention of cardiovascular disease: a meta-analysis of randomized controlled trials (Cochrane review).” American journal of hypertension vol. 24,8 (2011): 843-53. doi:10.1038/ajh.2011.115. https://pubmed.ncbi.nlm.nih.gov/21731062/
- Cobb, Laura K et al. “Methodological issues in cohort studies that relate sodium intake to cardiovascular disease outcomes: a science advisory from the American Heart Association.” Circulation vol. 129,10 (2014): 1173-86. doi:10.1161/CIR.0000000000000015. https://pubmed.ncbi.nlm.nih.gov/24515991/
- Hew-Butler, Tamara et al. “Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015.” Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine vol. 25,4 (2015): 303-20. doi:10.1097/JSM.0000000000000221. https://pubmed.ncbi.nlm.nih.gov/26102445/
- Whelton, P K et al. “Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.” JAMA vol. 277,20 (1997): 1624-32. doi:10.1001/jama.1997.03540440058033. https://pubmed.ncbi.nlm.nih.gov/9168293/
- Appel, L J et al. “A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.” The New England journal of medicine vol. 336,16 (1997): 1117-24. doi:10.1056/NEJM199704173361601. https://pubmed.ncbi.nlm.nih.gov/9099655/
- Zhou, Ming-Sheng et al. “Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?.” Diabetology & metabolic syndrome vol. 6,1 12. 31 Jan. 2014, doi:10.1186/1758-5996-6-12. https://pubmed.ncbi.nlm.nih.gov/24485020/
- Rabast, U et al. “Loss of weight, sodium and water in obese persons consuming a high- or low-carbohydrate diet.” Annals of nutrition & metabolismvol. 25,6 (1981): 341-9. doi:10.1159/000176515. https://pubmed.ncbi.nlm.nih.gov/7332312/.
- Volek, Jeff S., and Stephen D. Phinney. “A New Look at Carbohydrate-Restricted Diets: Separating Fact From Fiction.” Nutrition Today, vol. 48, no. 2, 2013, pp. E1–E7. doi:10.1097/NT.0b013e31828814eb. https://journals.lww.com/nutritiontodayonline/abstract/2013/03000/a_new_look_at_carbohydrate_restricted_diets_.11.aspx
- Weinstein, Jessica R, and Sharon Anderson. “The aging kidney: physiological changes.” Advances in chronic kidney disease vol. 17,4 (2010): 302-7. doi:10.1053/j.ackd.2010.05.002. https://pubmed.ncbi.nlm.nih.gov/20610357/
- Brown, Ian J et al. “Salt intakes around the world: implications for public health.” International journal of epidemiology vol. 38,3 (2009): 791-813. doi:10.1093/ije/dyp139. https://pubmed.ncbi.nlm.nih.gov/19351697/
- Liem, Djin Gie et al. “Reducing sodium in foods: the effect on flavor.” Nutrients vol. 3,6 (2011): 694-711. doi:10.3390/nu3060694. https://pubmed.ncbi.nlm.nih.gov/22254117/
- Faraco, G. et al. “Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response.” Nature Neuroscience 21, no. 2 (2018): 240–249. https://doi:10.1038/s41593-017-0059-z.
- Appel, Lawrence J., et al. “The Importance of Population-Wide Sodium Reduction as a Means to Prevent Cardiovascular Disease and Stroke.” Circulation, vol. 123, no. 10, 2011, pp. 1138–1143. https://doi.org/10.1161/CIR.0b013e31820d0793
